Leonard: "For God's sake, Sheldon, do I have to... hold up a sarcasm sign every time I open my mouth?"
Sheldon: "You have a sarcasm sign?"
Leonard: "I've dated plenty of women. There was Joyce Kim... Leslie Winkle..."
Sheldon: "Notify the editors of the Oxford English Dictionary. The word 'plenty' has been redefined to mean 'two.'"
Oh, gravity, thou art a heartless b-tch!Sheldon Cooper in The Big Bang Theory, Season 1 Episode 2
Leonard: "The key to acquiring proficiency in any task is repetition."
Sheldon: "...with certain obvious exceptions. Suicide for example!"
Quantum physics makes me so happy. It's like looking at the universe naked.Universe, Physics, Quantum MechanicsSheldon Cooper in The Big Bang Theory, Season 5 Episode 20
'See you in hell Sheldon'? The most frightening thing about that is the missing comma!Sheldon Cooper in The Big Bang Theory, Season 5 Episode 7
Sheldon: "I'm quite aware of the way humans usually reproduce, which is messy, unsanitary, and based on living next to you for three years, involves loud and unnecessary appeals to a deity."
Penny: "Oh God!"
Sheldon: "Yes, exactly."
You're asking me to use my superior intellect in a tawdry competition. Would you ask Picasso to play Pictionary? Would you ask Noah Webster to play Boggle? Would you ask Jacques Cousteau to play Go Fish?IntelligenceSheldon Cooper in The Big Bang Theory, Season 1 Episode 13
We dont need Wolowitz! Engineering is merely the slower younger brother of physics. Watch and learn! Do either of you know how to open the toolbox?Sheldon Cooper in The Big Bang Theory
Sheldon: "You do understand that our efforts here will in no way increase the odds of having sexual congress with this woman?"
Leonard: "Men do things for women without expecting sex."
Sheldon: "Those would be men who just had sex."
Howard: "Don't you think I should answer the engineering questions? I am an engineer."
Sheldon: "By that logic I should answer all the anthropology questions because I'm a mammal."
She is cheating. No one can be that attractive and this skilled at a video game.Nerds, Video gamesSheldon Cooper in The Big Bang Theory, Season 1 Episode 7
Penny: "Four years I lived with him! Four years, I mean that's like as long as high school!"
Sheldon: "It took you four years to get through high school?!"
Rajesh: "I don't know if I want to play anymore."
Sheldon: "Because you don't have a girlfriend? Well, good Lord, if that becomes a reason not to play Dungeons & Dragons, this game's in serious trouble."
Leonard: "I don't think I can go out with her tonight."
Sheldon: "Then don't."
Leonard: "Other people would say, 'Why not?'"
Sheldon: "Other people might be interested."
Leonard: "Penny's taking you to the DMV, I'm going to bed."
Sheldon: "Why Penny?"
Leonard: "Because rock breaks scissors."
Sheldon: "Well, once, when I was 15, spending the summer at the Heidelberg Institute in Germany."
Penny: "Studying abroad?"
Sheldon: "No. Visiting professor. Anyway, the local cuisine was a little more sausage-based than I'm used to. And the result was an internal Blitzkrieg, with my lower intestine playing the part of Czechoslovakia."
Leonard: "Sheldon, relax! She doesn't have any symptoms, I'm sure she's not contagious."
Sheldon: "Oh, please! If influenza was only contagious after symptoms appear, it would have died out thousands of years ago. Somewhere between tool using and cave painting, homo habilis would have figured out how to kill the guy with the runny nose."
Penny: "You'll never guess what just happened."
Sheldon: "I don't guess. As a scientist, I reach conclusions based on observation and experimentation. Although it occurs to me, you may have been employing a rhetorical device - rendering my response moot."
Smart? I'd have to lose 60 IQ points to be classified as smart.Sheldon Cooper in The Big Bang Theory, Season 2 Episode 2
Everybody's got a date. Even you, Mario, going after Princess Peach. And what am I doing? I'm just enabling you.Sheldon Cooper in The Big Bang Theory, Season 2 Episode 2
Well, at least now you can retrieve the black box from the twisted, smoldering wreckage that was once your fantasy of dating her and analyze the data so you don't crash into Geek Mountain again.Sheldon Cooper in The Big Bang Theory, Season 1 Episode 3
Leonard: "Well, do you have any ideas?"
Sheldon: "Yeah, but they all involve a Green Lantern and a power ring."
Penny: "Leonard isn't the kind of guy I usually go out with."
Sheldon: "Leonard isn't the kind of guy anyone usually goes out with."
My expenses account for 46.9% of my after-tax income. The rest is divided up between a small savings account, this deceptive container of peanut brittle and the hollowed-out buttocks of a superhero action figure who shall remain nameless for his own protection... or HER own protection.Sheldon Cooper in The Big Bang Theory, Season 2 Episode 14
Sheldon: "What are we doing here?"
Leonard: "We're socializing, meeting new people."
I'm sorry, but I'm not going to watch The Clone Wars TV series, until I've seen The Clone Wars movie. I prefer to let George Lucas disappoint me in the order he intended.Sheldon Cooper in The Big Bang Theory, Season 2 Episode 8
I've spent the past three-and-a-half years staring at greaseboards full of equations; before that, I spent four years working on my thesis; before that, I was in college, and before that... I was in the fifth grade.CollegeSheldon Cooper in The Big Bang Theory, Season 1 Episode 4
You tell people I'm a rocket scientist? My God! Why don't you just tell them that I'm a toll-taker at the Golden Gate Bridge?Sheldon Cooper in The Big Bang Theory, Season 1 Episode 15
Leonard: "Sheldon, how could you just sit there and let them spy on me?"
Sheldon: "They were clever, Leonard. They exploited my complete lack of interest in what you were doing."
If you have time to lean, you have time to clean.Sheldon Cooper in The Big Bang Theory, Season 1 Episode 2
This seat is ideally located both in relation to the heat source in the winter and a cross breeze in the summer. It also faces the television at a direct angle allowing me to immerse myself in entertainment or game play without being subjected to conversation. As a result, I've placed it in a state of eternal dibs.Sheldon Cooper in The Big Bang Theory, Season 3 Episode 22
Physics answers the question, "What is the nature of the universe?" Geology answers the question, "What'd I just trip over?"PhysicsSheldon Cooper in The Big Bang Theory, Season 11 Episode 7
I actually enjoyed being alone, solitude allowed me to think about important things.Solitude & Being AloneSheldon Cooper in Young Sheldon, Season 1 Episode 2
Of course, nobody I knew in East-Texas in 1989 cared about Newtonian Physics. The only Newtons they cared about were Wayne and Fig.TexasSheldon Cooper in Young Sheldon, Season 1 Episode 1
The average American consumes 55 pounds of beef per year. And then there's Texas, where we can knock that off in a couple of months. Maybe faster if we're talking about smoked brisket.TexasSheldon Cooper in Young Sheldon, Season 1 Episode 7
George: "Everybody knows you pun on fourth down."
Sheldon: "Why does everybody knowing something make it right?"
George: "Because... that's what makes this country great."
Sheldon: "Many years later, my brother would use the same argument in front of a judge. He was still convicted for urinating in a phone booth."
I don't need a calculator, dad. I am one.Sheldon Cooper in Young Sheldon, Season 1 Episode 5
In Texas, the holy trinity is God, Football and barbecue. Not necessarily in that order.TexasSheldon Cooper in Young Sheldon, Season 1 Episode 5
Science fact: Sisters are the worst.SistersSheldon Cooper in Young Sheldon, Season 1 Episode 2
Jane Goodall had to go to Africa to study the apes. I just had to go to dinner.Monkeys & ApesSheldon Cooper in Young Sheldon, Season 1 Episode 1
Engineering - where the semi-skilled laborers execute the vision of those who think and dream. Hello Oompa-Loompas of science!Sheldon Cooper in The Big Bang Theory, Season 1 Episode 12